Peppi Koivunen Selected Research

3,4-dehydroproline

12/2004

Many amino acid substitutions in a hypoxia-inducible transcription factor (HIF)-1alpha-like peptide cause only minor changes in its hydroxylation by the HIF prolyl 4-hydroxylases: substitution of 3,4-dehydroproline or azetidine-2-carboxylic acid for the proline leads to a high rate of uncoupled 2-oxoglutarate decarboxylation.

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Peppi Koivunen Research Topics

Disease

42	Hypoxia (Hypoxemia) 01/2022 - 08/2003
15	Neoplasms (Cancer) 12/2020 - 02/2007
7	Insulin Resistance 01/2022 - 10/2014
7	Inflammation (Inflammations) 01/2022 - 01/2016
4	Ischemia 01/2022 - 04/2010
4	Breast Neoplasms (Breast Cancer) 01/2019 - 01/2013
4	Carcinogenesis 01/2018 - 01/2013
3	Anemia 12/2016 - 04/2013
2	Weight Gain 01/2022 - 04/2016
2	Atherosclerotic Plaque (Atheroma) 01/2021 - 04/2016
2	Birth Weight (Birth Weights) 03/2020 - 11/2018
2	Fibrosis (Cirrhosis) 10/2017 - 01/2016
2	Lung Neoplasms (Lung Cancer) 08/2017 - 10/2014
2	Polycythemia (Erythrocytosis) 01/2017 - 01/2016
2	Obesity 04/2016 - 10/2014
2	Neuroblastoma 02/2016 - 10/2007
1	Gestational Diabetes (Gestational Diabetes Mellitus) 01/2022
1	Stroke (Strokes) 01/2022
1	Pregnancy-Induced Hypertension (Hypertension, Pregnancy Induced) 01/2022
1	Neuroinflammatory Diseases 01/2022
1	Body Weight (Weight, Body) 01/2022
1	Hyperglycemia 01/2022
1	Hypertrophy 01/2022
1	Gestational Weight Gain 01/2022
1	Dyslipidemias (Dyslipidemia) 01/2022
1	Metabolic Syndrome (Dysmetabolic Syndrome X) 10/2021
1	Non-alcoholic Fatty Liver Disease 01/2020
1	Wounds and Injuries (Trauma) 01/2020
1	Fatty Liver 01/2019
1	Alcoholic Fatty Liver 01/2019
1	Fetal Weight 11/2018
1	Inborn Genetic Diseases (Disease, Hereditary) 10/2017
1	Triple Negative Breast Neoplasms 06/2016
1	Atherosclerosis 04/2016
1	Sclerosis 01/2016
1	Albuminuria 01/2016
1	Melanoma (Melanoma, Malignant) 10/2014
1	Diabetic Retinopathy (Retinopathy, Diabetic) 06/2014
1	Pathologic Processes 04/2013
1	Neoplasm Metastasis (Metastasis) 04/2013
1	Kidney Diseases (Kidney Disease) 04/2013

Drug/Important Bio-Agent (IBA)

23	Oxygen (Dioxygen)IBA 01/2022 - 08/2003
13	Prolyl Hydroxylases (Prolyl Hydroxylase)IBA 01/2022 - 10/2007
10	EnzymesIBA 12/2020 - 03/2004
10	Transcription Factors (Transcription Factor)IBA 01/2019 - 03/2004
9	Glucose (Dextrose)FDA LinkGeneric 01/2022 - 04/2013
7	Proteins (Proteins, Gene)FDA Link 01/2022 - 01/2005
5	CollagenIBA 01/2021 - 01/2005
5	Mixed Function Oxygenases (Monooxygenases)IBA 01/2017 - 08/2005
4	IsoenzymesIBA 01/2022 - 04/2013
4	Succinate Dehydrogenase (Fumarate Reductase)IBA 12/2020 - 02/2007
4	Ketoglutaric Acids (Ketoglutaric Acid)IBA 01/2018 - 12/2004
3	Hemoglobins (Hemoglobin)IBA 01/2022 - 01/2021
3	Messenger RNA (mRNA)IBA 01/2022 - 01/2013
3	CholesterolIBA 01/2022 - 04/2016
3	Fumarate Hydratase (Fumarase)IBA 12/2020 - 02/2012
3	Isocitrate Dehydrogenase (Isocitrate Dehydrogenase (NAD+))IBA 12/2020 - 02/2012
3	Erythropoietin FDA Link 01/2017 - 01/2016
3	IronIBA 12/2016 - 04/2013
3	Succinic Acid (Succinate)IBA 02/2016 - 02/2007
3	FumaratesIBA 02/2016 - 02/2007
3	Pharmaceutical PreparationsIBA 01/2016 - 04/2013
3	Peptides (Polypeptides)IBA 09/2006 - 12/2004
2	Small Interfering RNA (siRNA)IBA 01/2022 - 10/2007
2	Histones (Histone)IBA 01/2019 - 01/2018
2	Histone DemethylasesIBA 01/2019 - 01/2018
2	alpha-hydroxyglutarateIBA 01/2019 - 03/2013
2	LipidsIBA 04/2016 - 01/2016
2	Estrogens (Estrogen)FDA Link 01/2013 - 05/2012
2	disodium salt olean-11,13(18)-diene-3,30-diol dihemiphthalateIBA 10/2007 - 09/2006
1	Triglycerides (Triacylglycerol)IBA 01/2022
1	Leucine (L-Leucine)FDA Link 01/2022
1	Amyloid Precursor Protein Secretases (beta-Secretase)IBA 01/2022
1	DioxygenasesIBA 12/2020
1	Choline (Choline Chloride)IBA 01/2020
1	FructoseIBA 01/2020
1	Methionine (L-Methionine)FDA Link 01/2020
1	Ethanol (Ethyl Alcohol)IBA 01/2019
1	Lipoproteins (Lipoprotein)IBA 01/2019
1	AntioxidantsIBA 01/2019
1	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2019
1	Ubiquitin-Specific ProteasesIBA 01/2018
1	Collagen Type I (Type I Collagen)IBA 10/2017
1	Glutamic Acid (Glutamate)FDA Link 06/2016
1	Cysteine (L-Cysteine)FDA Link 06/2016
1	AutoantibodiesIBA 04/2016
1	oxidized low density lipoproteinIBA 04/2016
1	LDL Receptors (LDL Receptor)IBA 04/2016
1	LDL Lipoproteins (beta Lipoproteins)IBA 04/2016
1	CopperIBA 04/2016
1	FG-4497IBA 04/2016
1	Adenosine Triphosphate (ATP)IBA 03/2016
1	PhosphofructokinasesIBA 03/2016
1	GlycogenIBA 03/2016
1	Adenosine Diphosphate (ADP)IBA 03/2016
1	Vincristine (Oncovin)FDA LinkGeneric 01/2016
1	Ferritins (Ferritin)IBA 12/2015
1	salinomycinIBA 10/2014

Therapy/Procedure

6	Therapeutics 01/2022 - 10/2014
1	Cardiopulmonary Bypass (Heart-Lung Bypass) 08/2017